Reverend Oliver Hart describes the first recorded symptoms of Harlequin type ichthyosis in 1750 -
"The skin was dry and hard and seemed to be cracked in many places, somewhat resembling the scales of a fish. The mouth was large and round and open. It had no external nose, but two holes where the nose should have been. The eyes appeared to be lumps of coagulated blood, turned out, about the bigness of a plum, ghastly to behold. It had no external ears, but holes where the ears should be. The hands and feet appeared to be swollen, were cramped up and felt quite hard. THE BACK PART OF THE HEAD WAS MUCH OPEN. IT MADE A STRANGE KIND OF NOISE, VERY LOW, WHICH I CANNOT DESCRIBE."
Three Lords celebrate the music of
a much open fetal skull
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